Sub-Acute Sclerosing Panencephalitis at University Hospital of Constantine

Main Article Content

Bouhdjila A
Benhacine Z

Abstract

Introduction Subacute sclerosing panencephalitis (SSPE) is a serious, late complication of measles, and the prognosis remains poor in the absence of effective treatment, underscoring the role of vaccination in its prevention.


Objectives We describe the clinicobiological and evolutionary profile of 16 patients recruited from the B chu de Constantine pediatric department.


Patients and methods Study of16 cases: epidemiological, clinical, EEG, biological and evolutionary profile.


Results16 cases of SSPE were collected, 75% were male, 70% were aged between 24 and 59 months, almost all patients had had measles, 98% within the first 24 months of life, 93% had not been vaccinated against measles, SSPE occurred in more than 50% of cases between 24 and 48 months after measles, all had received treatment (100% corticosteroids and immunoglobulins), 87% antiepileptics and 25% rituximab, the course was characterized by stabilization: 27%, death: 33% deterioration:40% of cases.


Comments and discussion SSPE is a rare complication occurring a few years after recovery from measles Almost all our patients had not been vaccinated against measles.


  in our patients, the median age at onset of SSPE was 4.5 years This earlier onset of SSPE in recent studies than reported in older studies suggests early onset of measles, viral mutation or a fragile immune system.


Almost all patients were unvaccinated against measles; 40% of patients died, 31% worsened (stage IV) and 37% stabilized.  


Conclusion Given the poor prognosis of SSPE, the best way to control this disease is to vaccinate the target population against measles.

Article Details

How to Cite
Bouhdjila A, & Benhacine Z. (2023). Sub-Acute Sclerosing Panencephalitis at University Hospital of Constantine. International Journal of Medical Science and Clinical Research Studies, 3(07), 1253–1259. https://doi.org/10.47191/ijmscrs/v3-i7-06
Section
Articles

References

I. .P. Lebon et all General reviewMeasles Sclerosing Subacute Pan Encephalitis(SSPE), an intriguing and ever-present disease:Data, assumptions and new perspectivesrevue neurologique 177 (2021)1059-1068

II. J. T. Jabbour Epidemiology of Subacute Sclerosing Panencephalitis (SSPE) A Report of the SSPE Registry

III. D.J. Brimani-aspects Atypiques De L'électro-Encéphalogramme Au Cours De La Panencéphalite Sclérosante Subaiguëatypic EEG Patterns In Subacute Sclerosing Panencephalitis 1990

IV. La panencéphasclérosante subaiguë : leucoencéphalite sclérosante subaigue Radermecker(1971),revue d’EEG et de neurophysiologie clinique

V. Millar JH. Subacute sclerosing panencephalitis. Clinical, pathological, epidemiological, and virological f indings in three patients. Q J Med 1968 ; 37 : 625-44.

VI. Connolly, J. H., Haire, M., & Hadden, D. S. M. (1971). Measles Immunoglobulin’s in Subacute Sclerosing Panencephalitis. BMJ, 1(5739), 23–25.

VII. Pascale Bonifas-Galup différents aspects cliniques et électro-encéphalographies de la pan encéphalite sclerosante subaigue (pess). A propos de 51 cas. rev. E.E.G. Neurophysiol., 1983, 13:224-231 Elsevier

VIII. Tanya lam A recent surge of fulminant and early onset subacute sclerosing panencephalitis (SSPE) in the united kingdom: an emergence in a time of measleseuropean journal of paediatric neurology 34 (2021) 43e49.

IX. Lebon et al La panencéphasclérosante subaiguë de la rougeoleUne maladie mortelle encore présente et toujours mystérieuse médecine/sciences 2022 ; 38 : 553-6).

X. V. Saha1 , t. JACOB JOHN1 * epidemiol. Infect. (1990), 104. 151-156 151 printed in great britain high incidence of sub acute sclerosing panencephalitis in south india.

XI. DOV SOFFER,' LOTTE RANNON,' A SUBACUTE SCLEROSING PANENCEPHALITIS: AN EPIDEMIOLOGIC STUDY IN ISRAEL vol. 103, no 1 printed inu SA.

XII. N Khetsurian High risk of subacute sclerosing panencephalitis following measles outbreaks in Georgia.Clin Microbiol Infect . 2020 Jun;26(6):737-742.

XIII. Hashimoto, K.; Hosoya, MAdvances in Antiviral Therapy forSubacute Sclerosing Panencephalitis.Molecules 2021, 26, 427.

XIV. MOHAMMED MEKKI1 | BRIAN ELEY2 | DIANA HARDIE3,4 | JO M WILMSHURST Subacute sclerosing panencephalitis: clinical phenotype, epidemiology, and preventive interventions